產(chǎn)品介紹：

Simoa^TM（Single Molecular Array）又稱(chēng)作數字式ELISA，是基于Simoa HD-1數字式單分子免疫陣列分析儀，可直接對血清和血漿中蛋白、核酸等生物標志物進(jìn)行檢測的技術(shù)。它的檢測靈敏度比傳統的免疫檢測技術(shù)平均高1000倍以上，將蛋白質(zhì)檢測技術(shù)直接帶入單分子、數字化檢測時(shí)代，成為fg級超低豐度蛋白質(zhì)檢測領(lǐng)域的優(yōu)勢技術(shù)。

技術(shù)原理：

1、將捕獲抗體偶聯(lián)到磁珠上，磁珠與目標抗原結合，目的抗原與檢測抗體結合并帶有梅標記。

2、洗滌磁珠以去除非特異性結合的蛋白，加入酶反應底物。

3、將加入底物的磁珠轉入Simoa光盤(pán)上，將熒光信號封閉在小孔內。

應用領(lǐng)域：

Simoa技術(shù)可用于腫瘤、神經(jīng)、感染性疾病、免疫炎癥、miRNA檢測，特別是癌癥的早期檢測、術(shù)后的監測和精準用藥，將極大推動(dòng)精準醫療的發(fā)展。運用Simoa可檢測到的低濃度生物標志物進(jìn)行準確分析，為生命科學(xué)研究、體外診斷、伴隨診斷和血液篩查等領(lǐng)域。目前在全球引用該技術(shù)發(fā)表的文獻有200多篇，包括高分雜志Nature, Nature Biotechnology, JEM, JAMA Neurology等。

參考文獻

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